This study provides design and implementation of four digital filters (low pass, high pass, band pass and band stop) for ECG (electrocardiogram) data on FPGA with MATLAB by a serial communication. The study is conducted with using ECG data which is obtained from PhysioBank Database platform. SysGen (System Generator for DSP) which is a toolbox for MATLAB is used for designing and implementing the digital filters. The aim of the study is to perform four different digital filters with various blocks on the SysGen Toolbox. The study then examines the results of four different digital filters.