The life quality of the patients with plegia and their caregivers is drastically reduced in daily life. Quadriplegia, which means that four limbs and the body trunk are affected from the plegia, is known as the most severe type of plegia. Since patients with quadriplegia can only move their eyes in their bodies and cannot meet their needs themselves, this limits them both psychologically and physically. In this study, a new system is proposed to use the device control interface in front of the patient via their eye movements and hence to control a device (or devices) whichever they want. Therefore, an improvement in both the patient’s and their caregivers’ life qualities since the patients will be able to conduct some simple activities alone. As a result of the limited experiments, to turn on and turn off the preprogrammed devices are controlled using the proposed system successfully.